Jade Leung

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Photo-Illustration by TIME (Source: Courtesy of Jade Leung)

Pay packages in the AI industry are some of the most generous in tech. Salaries in the U.K. government… not so much.

So Jade Leung took a big pay cut when, in October 2023, she quit her job at OpenAI to become chief technology officer to the U.K. government’s new AI Safety Institute (AISI). Established in late 2023, the U.K. AISI has in a short time become the leading government body, anywhere in the world, dedicated to testing the safety of the most powerful AI systems.

The move was worth it, Leung says, because of the opportunity to shape the way that AI systems are governed. “You really want a public interest body that is genuinely representing people to be making those decisions,” she says. “By definition, they need to be [taken] outside of the organizations developing” AI models.

Leung’s role at the U.K. AISI has largely been focused on building it into a body that can carry out state-of-the-art safety research. Alongside staffing up the nascent organization, her key responsibility is designing and overseeing evaluations that can test whether AI models pose the risk of being used to facilitate cyber, biological, or chemical attacks. The organization has also been developing a more speculative set of tests designed to check whether AI systems have the ability to escape the control of their designers. The U.K. government has negotiated early access to new models from leading AI companies to carry out safety testing on them; the AISI has completed two such tests already, one of them on Anthropic’s Claude 3.5 Sonnet model. “We are currently, I would say, the best single place that you could go to to have your models evaluated across a range of frontier AI risk areas in a fairly robust and in depth way,” Leung says.

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Sundar Pichai

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Time100 AI Sundar Pichai
Photograph by Helynn Ospina

It’s hard to imagine what modern life would look like without Google. Its search business prints hundreds of billions of dollars in yearly revenue, and starting over two decades ago, Google began channeling some of that money toward AI research. Its industry-leading scientists were responsible for many of the breakthroughs that drove the field to its current inflection point. And yet the product that in late 2022 kick-started today’s AI boom, ChatGPT, came from a startup backed by Google’s major competitor, Microsoft. Suddenly Google was no longer the symbolic leader of the AI race, but instead playing catch-up.

Google’s CEO Sundar Pichai, who joined the company in 2004 and was appointed to the top job in 2015, took that hurdle in stride. Google wasn’t the first to build a search engine, he points out, but was the first to build one good enough to attract the lion’s share of the market. The same for browsers. Email. Maps. His point: it matters less whether Google is first, and more that its version is the best. The U.S. Department of Justice takes an alternative view: that Google’s search is a monopoly upheld by illegal anti-competitive actions. On Aug. 5, a judge ruled in favor of that argument; Pichai says Google plans to appeal.

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Satya Nadella

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Photo-Illustration by TIME (Source: Courtesy of Satya Nadella)

Back in 1993, the man who would eventually become Microsoft’s CEO was working as a marketing manager at the company. A video from that year shows Satya Nadella, wearing a pair of ’70s-style spectacles and full head of hair, explaining the merits of a powerful nascent technology: Microsoft Excel.

More than three decades later, after climbing to the pinnacle of the tech giant, Nadella's work is pushing the world towards something far bigger: artificial general intelligence (AGI). It was he who, in 2019, presided over Microsoft’s decision to invest its first billion into an obscure AI lab called OpenAI and, in the years that followed, grew that partnership into a profit-sharing deal worth more than $13 billion. OpenAI needed Microsoft’s help in its effort to build AGI because of the tech giant’s prowess in cloud computing, the arm of the company that Nadella grew into a global leader before he became CEO, and which is essential for the creation of modern AI.

Nadella has also proven himself to be a shrewd corporate maneuverer. When OpenAI’s board briefly fired Sam Altman in late 2023, Nadella offered all OpenAI employees jobs at his own company, essentially neutralizing the board’s threat and clearing the way for Altman’s return. Since that high drama last November, Nadella has moved to reduce Microsoft’s reliance on OpenAI, investing $16 million into the rival French AI lab Mistral, and separately hiring a team of world-leading researchers to begin a parallel effort, inside Microsoft, to build its own large language models.

*Disclosure: OpenAI and TIME have a licensing and technology agreement that allows OpenAI to access TIME's archives.

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Sasha Luccioni

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Photo-Illustration by TIME (Source: Courtesy of Sasha Luccioni)

About 5 years ago, Sasha Luccioni was researching ways AI could help tackle climate change when a single question prompted her to rethink: What if AI was part of the problem?

“Every time you do a Google search, you don't know how much energy that's using. Every time you use an AI to generate an image, you don’t know how much energy that’s using,” Luccioni says. The tech industry, she says, has not been forthcoming with data about the carbon footprint of this new technology. 

That revelation spurred Luccioni to examine AI’s environmental costs. In 2020, she helped create a tool for developers—which has since been downloaded over one million times—to quantify the carbon footprint of running a piece of code. Two years later, she co-authored one of the first studies to calculate the carbon generated by a large language model. The study estimated that BLOOM, which at the time was the world’s largest multilingual open-source AI model, would generate over 50 metric tons of CO2 over its life cycle. That’s roughly the equivalent of flying from London to New York and back about 80 times.

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Sam Altman

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Photo-Illustration by TIME (Source: Halil Sagirkaya—Anadolu/Getty Images)

Last year was a huge one for Sam Altman. The OpenAI CEO rocketed to household name status, was sought by dozens of world leaders for his audience, and saw his personal wealth balloon, all thanks to the success of ChatGPT. But just before Thanksgiving, the rocket engine faltered. OpenAI’s nonprofit board fired Altman, saying he had been dishonest with them. Altman eventually saw off the board’s threat, and was back in the top job by the time he sat down for home-cooked vegetarian pasta on Thanksgiving. But to many observers—if not for his many allies in Silicon Valley—the events had tarnished Altman’s golden year.

In 2024, as well as shepherding OpenAI through several new products including a voice assistant, a synthetic video generator, and an AI search engine, Altman resumed his project of smoothing the ground for OpenAI’s future plans. In February, it emerged he was seeking up to $7 trillion from investors in an audacious attempt to build a new manufacturer of the chips necessary to build cutting-edge AI, seeking to loosen some of Nvidia’s stranglehold of the market. And in July, he published a manifesto of sorts in the Washington Post, arguing that for democracies to succeed against authoritarianism, they must improve their cybersecurity, invest more deeply in AI hardware, and collaborate with China on setting global norms for AI deployment. 

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Jensen Huang

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Photo-Illustration by TIME (Source: Annabelle Chih—Bloomberg/Getty Images)

The leather-jacketed CEO of Nvidia has long been seen as something of a tech rockstar. But it was presumably a first even for Jensen Huang when, at a tech expo in Taipei in June, a woman asked him to sign her chest with a permanent marker. The request, which he obliged, was only the most outrageous example of “Jensanity,” the phenomenon that has catapulted Huang into the ranks of celebrity CEOs.

Thanks to its chips being used as the backbone of cutting-edge AI systems, Nvidia’s stock price has more than doubled since the start of the year, and at its 2024 peak had risen nearly eight-fold since the 2022 release of ChatGPT. A couple of weeks after that conference in Taipei, Nvidia briefly became the world’s most valuable company, worth north of $3 trillion.

Nvidia got its start designing graphics processing units, or GPUs, for the video game industry. Unlike the brains of a standard computer, which does long strings of calculations in sequence, a GPU makes multiple simultaneous calculations in order to render cutting-edge graphics. Nvidia is expert at designing chips that do this so-called parallel processing. It was a stroke of luck that neural networks, the kinds of algorithms that power most modern AI, use the same type of processing. Suddenly the demand for Nvidia’s GPUs was coming not just from gamers, but also machine learning engineers.

Huang spotted the opportunity earlier than many of his competitors, and Nvidia began designing bespoke chips for AI research and building relationships with labs. A photo from 2016 shows him hand-delivering an early Nvidia supercomputer to OpenAI. Scrawled on the machine in black permanent marker were Huang’s now-familiar signature and a toast: “To the future of computing and humanity.”

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Rohit Prasad

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Photo-Illustration by TIME (Source: Courtesy of Rohit Prasad)

Developing artificial general intelligence (AGI)—or an AI smart as a human—is the “north star” for Amazon’s Rohit Prasad, who jumped from being Alexa’s head scientist to running a newly-created Amazon AI team last year. While the retail tech juggernaut trails in the large language model (LLM) race against competitors like Microsoft and Google, it hopes to leverage its formidable resources to build an LLM.

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Cari Tuna

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Photo-Illustration by TIME (Source: Marvin Joseph—The Washington Post/Getty Images)

When, in 2015, Open Philanthropy first donated over $1 million towards reducing the risks of advanced AI, few people took the threat seriously. That has changed. 

Cari Tuna is the president of the nonprofit, which administers the philanthropic endeavors of her and her husband, Facebook and Asana co-founder Dustin Moskovitz. Under her leadership, the organization has made large donations to influential think tanks and researchers exploring ways to reduce the potentially catastrophic threats posed by artificial intelligence, among other causes like global health. In fact, Open Philanthropy’s grants and investments have drawn scrutiny for targeting the most extreme dangers of AI—like AI aiding terrorists or going rogue—in favor of more concrete current harms like bias. “Today’s AI biases foreshadow tomorrow’s critical risks,” Tuna wrote in an emailed statement. “I’m proud to support research to better understand how these systems work and how to make them reliable and safe.”

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Zhuang Rongwen

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Photo-Illustration by TIME (Source: Ni Yanqiang—Reuters)

As the Director of the Cyberspace Administration of China (CAC), the country’s leading AI regulator, Zhuang Rongwen faces a seemingly impossible task: imposing the nation’s censorship practices on unpredictable generative AI technology without stifling domestic innovation.

That did not stop Mr. Zhuang from making history in August 2023, when less than a year after ChatGPT was released, China became one of the first countries to implement binding regulation targeting generative artificial intelligence. The law requires, among other things, for developers to obtain government approval before deploying models publicly. Since then, the government has approved over 40 Chinese language models, including those of newly-minted Chinese AI unicorns like Zhipu and Baichuan. China is second only to the United States in the number of large-scale AI models originating from the country, accounting for 25% of such models. 

A provision in the law states that AI developers must “Uphold the Core Socialist Values.” Perhaps leading by example, a research arm of the CAC created its own LLM in May. Dubbed ‘Chat Xi PT,’ the model was trained on the political doctrine of President Xi Jinping as well as other official literature. For now, the model is for internal use only.

But the CAC under Zhuang has also been instrumental in curtailing the power of China’s biggest tech companies. In the summer of 2022, the regulator issued a $1.2 billion fine to China’s leading ride-hailing company, Didi, for violating data security laws. The massive fine was a part of a multi-agency crackdown on China’s tech industry that wiped out more than $1 trillion in value from the sector. 

While the crackdown has since eased, there is no guarantee it will last. Zhuang’s decisions will help shape whether China can keep pace with its western counterparts and realize its aspirations of becoming an AI powerhouse. 

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Mark Zuckerberg

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Photo-Illustration by TIME (Source: Courtesy of Mark Zuckerberg)

A couple of years ago, it looked like Mark Zuckerberg’s influence may have peaked. Beset by safety scandals, he renamed Facebook to Meta and poured billions of dollars into creating the “metaverse.” The billionaire CEO hoped to foster a new era of technology, but it was a false start. Amid consumer ambivalence and heavy spending on research and development,

Meta’s market valuation slid from a high of $1.07 trillion in summer 2021 to $240 billion in early November 2022, the eve of OpenAI releasing ChatGPT.

Anyone counting Zuckerberg out at that point would have been wrong. The Meta founder was early to the world of AI, first hiring some of the world’s best researchers back in 2013. And after ChatGPT ignited the generative AI boom, he quickly reoriented his company around the technology. Meta’s Llama series of models are now some of the most powerful outside of OpenAI, Anthropic or Google. And in a significant break from those leading labs, Zuckerberg decided to publish the “weights”—essentially the underlying neural networks—of the Llama models online. By allowing the open-source community to build on top of Meta’s AI, Zuckerberg applied unwelcome pressure to his competitors, who profit from selling customers access to their proprietary models. He also aligned Meta with those who believe no single company should have a monopoly on the best technology, helping attract talented AI researchers in a highly competitive labor market. That position may surprise some, given that Meta has in the past been accused by the Federal Trade Commission of monopolistic practices in other areas of its business. And it has rankled some open-source purists, who argue that Llama models’ open source licenses come with restrictions that fall short of true openness. Nevertheless, it has worked wonders on the market, with Meta stock surging to new highs this year. Back in a position of power, Zuckerberg announced in January that his company was now, much like other leading labs, also working toward “artificial general intelligence.”

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Demis Hassabis

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Photo-Illustration by TIME (Source: Theo Wargo—Getty Images)

When Demis Hassabis co-founded DeepMind in 2010, he had a 20-year plan culminating in the creation of artificial general intelligence (AGI), an AI system that can do practically any cognitive task a human can. 14 years on, Hassabis thinks things are on track.

 “I believe [AI] is going to be the most beneficial technology ever created, but only if we apply it in the right way and build it in the right way,” he said at a talk hosted by the payments platform Stripe earlier this year.

Known as Google DeepMind since its 2014 acquisition, Hassabis’ lab has had many successes, including pioneering “deep reinforcement learning,” designing systems that beat the best human players at the board game “Go,” and solving the protein folding problem to help scientists design new drugs and understand diseases. 

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C.C. Wei

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Photo-Illustration by TIME (Source: Carlos Garcia Rawlins—Reuters)

Dr. C.C. Wei is in charge of the world’s largest contract semiconductor manufacturer, Taiwan Semiconductor Manufacturing Company (TSMC), having served its CEO since 2018, and its Chairman since June 2024.

TSMC, whose clients include Apple, NVIDIA, and AMD, has taken on new importance amidst the ongoing AI boom—it is the only company in the world currently capable of fabricating the cutting-edge chips that power the most advanced AI systems. Its market value has nearly tripled over the past six years.

The company’s unparalleled manufacturing capabilities, combined with the strategic importance of its product, puts it in a fraught position in relation to the tensions between the U.S. and China. Wei is careful about what he says about this relationship in public. Reflecting on his career during a talk at Yale, his alma mater, Wei said with an apologetic smile “I was not allowed to give a speech without going through my legal department…I don’t make a public comment on China,” going on to note that many of TSMC’s customers were from China.

Wei has been at the company since 1998. Under his leadership, TSMC has initiated a significant global expansion beyond Taiwan, with plans for new advanced chip factories in the United States and Germany, and ongoing construction in Japan.

TSMC has been one of the beneficiaries of billions of dollars of subsidies provided under America’s CHIPS Act. To date, they have been awarded over $6 billion to support the construction of a factory in Arizona. There’s a “huge amount of talented people” in America, Wei told Yale students. He believes the company’s westward expansion is an opportunity for it to recruit and build towards the future.

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Masayoshi Son

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Few people spot the next big trend as consistently as Masayoshi Son. Under his leadership, Japan’s SoftBank pivoted from an internet broadband provider into a mobile phone network company and most recently an investment giant boasting assets worth $180 billion. Today, Son is pivoting again into what he believes will be the key source of future growth: AI, which he’s backing with $9 billion a year in investments. In May, SoftBank led an investment of over $1 billion into British self-driving car start-up Wayve, in Europe’s largest AI deal to date. Under the majority ownership of Softbank, leading semiconductor firm Arm is also rolling out a new generation of AI-enabled chips. But Son is not just a champion of AI—he’s embraced the technology with the zeal of a convert, backing ASI, or artificial super intelligence, to become “10,000 times smarter” than humans in a decade. “Softbank was founded to realize ASI,” he told an annual shareholder’s meeting in June. “Masayoshi Son was born to realize ASI.”

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Faisal Al Bannai

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Photo-Illustration by TIME (Source: TIME)

In 2023, the Advanced Technology Research Council (ATRC), an arm of the Abu Dhabi government, spent millions of dollars building a series of large language models. ATRC secretary general Faisal Al Bannai then decided to release them online for free, reasoning that if they were as good as the team’s internal testing showed, it would bolster the UAE’s credibility and attract talent. It worked. The models, named Falcon after the UAE’s national bird, were by some metrics the best open source models at the time of their release, beating offerings by Meta and Google. “⁠I mean, two years ago, how many people would refer to UAE on the map of AI? Not many,” Al Bannai told TIME in February. Falcon changed that.

Al Bannai says the focus is now on multimodality and getting better performance with less. To that end, the ATRC released two smaller models earlier this year: one with vision capabilities, and another based on a novel architecture. Al Bannai says he’s working on a larger, multimodal model that will compete with the likes of OpenAI’s GPT-4o.

It’s important that countries have a compelling open source alternative to the “proprietary AI from the large players,” he says. At home, a version of Falcon is being rolled out in the UAE’s healthcare system. Meanwhile, several states, including Serbia, Uzbekistan, and the Brazilian state of São Paulo, have bought into Al Bannai’s open source vision, inking deals with the UAE to use its models. 

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Liang Rubo

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Photo-Illustration by TIME (Source: Bytedance)

Americans already know ByteDance as owner of social media phenomenon TikTok, which Congress ruled in March would be banned in the U.S. unless its Beijing-based parent divests. However, ByteDance is also making huge strides in AI under the leadership of Liang Rubo, who replaced his former roommate and co-founder, Zhang Yiming, as chief executive in 2021. In May, the company released an AI model, dubbed Doubao, which has overtaken Baidu’s ERNIE as China’s most popular chatbot and costs 99.8% less to run than OpenAI’s ChatGPT4, according to ByteDance. But if the company has been given a rough ride by U.S. lawmakers over TikTok, don’t expect any softening when it comes to broader AI applications, with Washington determined to maintain any competitive advantage via export controls. In response, ByteDance is investing $2 billion to develop an AI hub in Malaysia and is negotiating with Broadcom to design an advanced AI chip. Seizing on the potential of AI has become something of an obsession for Liang, who went viral for lambasting colleagues for being slow to identify the technology’s potential. “This is an era of great change,” Liang told a company meeting in January, urging staff to “escape the gravity of mediocrity.”

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Wang Xiaochuan

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Photo-Illustration by TIME (Source: Courtesy of Wang Xiaochuan)

Wang Xiaochuan had been marked for greatness from a very young age. The Chengdu native won first prize in China’s National High School Maths Competition aged 14 and a gold medal in the International Olympiad in Informatics at 17. He founded his first company while still a student at China’s prestigious Tsinghua University and became a vice-president of the nation’s second most popular search engine, Sogou, at just 27. It was after stepping down as CEO of Sogou in 2021 that Wang focused his undoubted intelligence on the artificial variety. In April 2023, he founded Baichuan AI, and within six months had already raised $300 million from investors like Alibaba and Tencent, making it one of the fastest companies to achieve unicorn status ever. Wang hasn’t disappointed; in May, Baichuan released its fourth generation large language model, which the company says outperforms competitors in several key metrics. The Beijing-based company—valued at $2.7 billion today—has also unveiled an AI assistant, Baixiaoying, which has the unique ability to ask users follow-up queries to figure out their intentions and better tailor responses. “We're the only one doing this—to guide and inspire a user to clearly articulate what they need,” Wang told an industry event in May.

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Lisa Su

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Lisa Su
I-Hwa Cheng—AFP/Getty Images

Lisa Su is acutely aware that technology is all about making the right bets. In her 10 years at the helm of chipmaker Advanced Micro Devices (AMD), she has steered one of Silicon Valley’s greatest turnarounds by focusing on its strengths and strategic dealmaking. When she took over at the company in 2014, its share price was languishing around $3. By leaning into making central processing units (CPUs) for laptops and PCs, and graphics processors, used in gaming consoles and PCs, Su brought AMD onto more stable footing, strengthening tactical partnerships with companies including Sony and Microsoft. In recent years, AMD has closed the $49 billion purchase of competitor Xilinx—the largest semiconductor deal ever—as well as the $1.9 billion acquisition of data center networking company Pensando.

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Jonathan Ross

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Photo-Illustration by TIME (Source: Courtesy of Jonathan Ross)

Jonathan Ross had already made his name at Google, designing the custom chips that the company would go on to train its AI models on, when Amazon and Microsoft came calling. It was 2016, and both companies tried to poach him to help build their own chips, he says. One of the suitors—Ross won’t say which—privately told him that it would be bad for the world if Google and China were the only two entities in charge of the world’s most advanced AI, and that he should help them to become a check on their power. “Three’s not that much better than two,” Ross recalls thinking at the time. “But I like your pitch—I’m going to go do this and make it available for everyone.”

That’s the founding story, as Ross tells it, of Groq, now one of the buzziest AI chipmaking startups in Silicon Valley. Groq’s chips, called language processing units (LPUs), aren’t designed for the initial training period of AI models. Instead, they’re optimized to run large language models as fast as possible once they’ve been created. What distinguishes LPUs from others is their efficiency: 10 times faster and 10 times cheaper to run, according to a Groq slide deck, than industry-standard graphics processing units (GPUs). On stage at a conference in Dubai in February, Ross demonstrated the speed of a Meta chatbot running on a cluster of Groq LPUs. It spit out several paragraphs in seconds, much faster than the industry standard. The ground, however, is shifting fast: Cerebras Systems claimed on Aug. 27 that its cloud platform is twice as fast as Groq's and 20 times as fast as GPU-based rivals.

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Victor Riparbelli

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Photo-Illustration by TIME (Source: Courtesy of Victor Riparbelli)

Deepfakes as a service: that’s Synthesia’s business model. But it’s not what it sounds like. The London-based AI company offers businesses a platform to turn any document or webpage into an engaging video hosted by a realistic AI avatar (resembling either you the user, or an actor whose likeness Synthesia has paid to license) that can change its expressions, body language, and intonations based on the text it’s reading. In June, the company launched a service allowing customers to create an avatar of themselves using a laptop webcam in as little as 5 minutes. Victor Riparbelli, Synthesia’s CEO, explains that most humans learn more easily from watching a video than they do from reading. AI-generated video is glitchy and not ready for prime-time, he says, but Synthesia is targeting use cases where viewers don’t tend to care. “Our product is not made for making the next Super Bowl ad,” Riparbelli says. “It’s much more made for [clients who say], ‘We have a help-center article, make a quick video that explains the content.’”

Synthesia is also battling against the seedier ways that people are using AI-generated video. Political deepfakes, showing election candidates saying things they never said, have surfaced in elections in India and Slovakia so far this year, although with fewer adverse effects than some had anticipated. More devastatingly, the technology has been used to produce an epidemic of sexualized harassment of women and girls, their likenesses superimposed onto explicit videos without their consent. Synthesia lobbied the U.K. government to ban the creation and sharing of sexually explicit deepfakes–a law that came into effect in April. On its own platform, Synthesia requires users to upload a verification video of themselves reading a script, to ensure that individuals can’t make AI avatars of other people. “I would hope most people agree that non-consensual deepfakes, nobody wants that,” says Riparbelli. “And I think it’s very positive that we’re making policies against that.”

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Aravind Srinivas

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Photo-Illustration by TIME (Source: Saul Loeb—AFP/Getty Images)

Online, Aravind Srinivas displays swagger. In person, the 30-year-old has the demeanor of a man not used to being the center of attention. Sitting down for an interview in May, the CEO of the AI “answer engine” Perplexity is told that his potential inclusion in the TIME100 AI was not yet final and the decision could still change in the months ahead. “OK,” he says. “So as long as I don’t f-ck up…”

By then, Perplexity had already drawn the ire of online publishers for its business model: using AI to answer users’ questions by summarizing websites, diverting ad revenue from those sites. In June, the company launched a new feature called “Perplexity Pages,” that creates AI-generated reports in response to users’ queries. The feature appeared to have plagiarized sections of reporting from multiple publications, while barely or inaccurately citing its sources.

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Daphne Koller

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Photo-Illustration by TIME (Source: Taylor Hill—Getty Images)

One of the most oft-dreamed applications of artificial intelligence is using it to pioneer new screenings, treatments, and interventions for diseases. This is precisely what Daphne Koller is trying to do at Insitro, where she’s founder and CEO.

Insitro uses machine learning tools to scan genetic samples from people with diseases like ALS, cancer, and tuberous sclerosis. It then tries to identify causal mechanisms that human researchers may have missed. Koller describes it as a collaborative environment, where people with backgrounds in fields like machine learning, metabolic disease research, and statistical genetics often work together.

From the outside, Koller’s path may not look like a straight one: she was a faculty member of Stanford’s computer science department and co-founded the online learning company Coursera in 2012, before founding Insitro in 2018. 

“I've had this increasing sense of urgency to make an actual direct impact in the world,” Koller says. While observing the beginning of exponential growth in AI capabilities in 2016, she felt an urge to help unlock its real-world potential.

“You could use [AI] for things like making a better sales chat bot—and I'm not trying to dismiss that, but I think you can also come up with more aspirational use cases for this incredible technology,” she says. 

Insitro’s research into ​​nonalcoholic fatty liver disease, Koller says, has advanced to animal trials. The company also plans to apply for a clinical trial for a human drug in the coming months. Six years in, Koller is excited by Insitro’s progress, but says it’s crucial not to play into the AI-hype cycle that’s so common in the tech world.

“What we're doing is really hard—intervening in human biology in a way that is both safe and efficacious,” Koller says. “So it's important to not make extravagant promises that are just not the right ones for this space.”

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Sarah Gurev

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Photo-Illustration by TIME (Source: Courtesy of Sarah Gurev)

With each new variant of SARS-COV-2—not to mention annual variants of the flu—another wave of people are sickened, and their lives disrupted. Viruses mutate and evolve, keeping ahead of vaccines. EVEScape aims to predict those evolutions and mutations by using artificial intelligence. The project, which is co-led by Sarah Gurev, a doctoral student at Harvard Medical School in the Debora Marks Lab, uses AI to process data on viral evolution over an extended period, alongside information on the biology and structures of different viruses. The team, including co-leaders Nicole N. Thadani, Debora Marks, Pascal Notin, and Noor Youssef, published a study last fall showing that if the tool had been available at the start of the pandemic in 2020, it would have been able to predict the most concerning variants before they appeared. Gurev designed the AI models that underpinned those predictions.

Gurev and her colleagues also collaborate with labs that can evaluate vaccines and therapies that can stop future variants of a virus from wreaking havoc. “The direct partnership between computationalists and experimentalists will really drive AI to become impactful in different biological applications,” she says.

Gurev and her collaborators are now using the tool to keep up with the Lassa and Nipah viruses, which lead to serious illnesses in West Africa and South Asia respectively, and are more virulent that SARS-COV-2 but much less studied. Vaccine design is typically slow and laborious, but AI may speed up and streamline the process. Gurev says the tool can also help researchers design broader coronavirus vaccines that would be “future proof.”

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Mustafa Suleyman

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Photo-Illustration by TIME (Source: Courtesy of Mustafa Suleyman)

This March, Mustafa Suleyman left his startup Inflection AI to become the CEO of Microsoft AI, a newly-formed unit focused on the company’s consumer artificial intelligence research and products, like Copilot, Bing and Edge. Almost all of Inflection’s staff followed Suleyman to Microsoft from the startup that was valued at $4 billion. At the same time, Microsoft inked a $650 million deal with the startup to access its AI models.

Suleyman took a humanistic approach to technology with his strategy at Inflection. The company sought to create the first “emotionally intelligent” chatbot. In a TED Talk, a month after joining Microsoft, he described himself as someone “who’s always cared deeply about [technology’s] ethics.” Back in 2018, while at DeepMind—the Google-owned AI lab he co-founded—Suleyman signed an open letter endorsing a ban on lethal autonomous weapons.

Yet he has become embroiled in some ethical tangles of his own. He departed DeepMind in 2019 following accusations that he had bullied his staffers. He later apologized for his behavior. More recently, Microsoft’s arrangement with Suleyman and Inflection came under regulatory scrutiny, with the U.K. Competition and Markets Authority launching an investigation into whether it constituted a merger. On Sept. 4, the watchdog cleared the deal, saying that, while it qualified as a merger, it did not cause competition concerns. Microsoft and Inflection had said that they would cooperate with the watchdog. Microsoft added that it believes hiring talent promotes competition and shouldn’t be treated as a merger.

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Shiv Rao

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Photo-Illustration by TIME (Source: Michael Nagle—Bloomberg/Getty Images)

Doctors often complain that for every hour they spend with patients, they spend up to two on paperwork. This homework even has a name: “pajama time.” The paperwork deluge is more than just soul-crushing—it’s contributing to what Shiv Rao, the co-founder and CEO of AI-powered medical scribe startup Abridge, describes as a “public health emergency” of doctor burnout.

“Nothing crushes my soul more than having to come home after clinic and know that I have three hours in front of the TV at night just documenting,” says Rao, a practicing cardiologist at the University of Pittsburgh Medical Center.

With a patient’s consent, Abridge records a doctor visit, automatically transcribes it, and creates a summary for the patient and other physicians. Doctors seem to love Abridge, according to a study conducted by the healthcare research firm KLAS Research. Rao also reports a “waterfall” of glowing feedback.There are other companies in the AI-medical scribe industry—most notably Nuance, which Microsoft bought for $20 billion in 2022. But even Nuance’s former long-time CEO and chairman, Paul Ricci, has observed Abridge's leadership in the space. “I think Abridge is ahead technologically. I think they’re ahead in terms of deployment,” Ricci told Forbes in February. Now serving as an advisor to venture capital firm Lightspeed, Ricci oversaw the group's investment in Abridge in 2023. Rao says they have roughly 50,000 clinicians contracted to use Abridge, with about half coming from a partnership with healthcare giant Kaiser Permanente. But Rao doesn’t want to stop there. “We want to be a part of every single medical conversation for every single patient,” he says. 

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Zack Dvey-Aharon

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Photo-Illustration by TIME (Source: Courtesy of Zack Dvey-Aharon)

More than half of people living with diabetes are at risk of losing their eyesight due to complications from a disease called diabetic retinopathy. That’s about 500 million people globally, and 40 million in the U.S. The condition is almost fully preventable if detected in time, but estimates suggest only half of those people get the necessary annual screening.

A new AI-powered screening system by AEYE Health, a company co-founded by Zack Dvey-Aharon, reduces diagnosis of diabetic retinopathy to a minute, via a handheld camera and a single image of each retina — all without the need for a physician in the loop. 

The system, called AEYE-DS, received FDA approval in April, after rigorous testing to ensure it worked across a range of demographics and situations. It is the first FDA-approved device of its kind. Its low cost and portability could make this screening accessible to millions of people who need it, starting in America. It is currently in use in hundreds of locations across the country.

In a conversation with TIME, Dvey-Aharon said that, since receiving FDA clearance, AEYE Health was working with partners to significantly expand the technology’s availability. These screenings can also be claimed back from insurance.

Screening for diabetic retinopathy is only the start of what AEYE Health’s systems hope to achieve. Dvey-Aharon’s company is working on using AI to screen for a wider range of conditions, including cardiovascular disease, glaucoma, and hypertension. Retinal scans are particularly useful for medical diagnosis, Dvey-Aharon explains, because the eyes offer “a direct view to blood vessels.”

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Mira Murati

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Photo-Illustration by TIME (Source: Carl Timpone—BFA/Shutterstock)

It’s been a tumultuous 12 months for Mira Murati, one of the driving forces behind OpenAI’s meteoric rise. As the company’s chief technology officer, Murati worked behind the scenes to guide models like ChatGPT and DALL-E to mainstream adoption. But last November she was thrust into the spotlight when she was appointed interim CEO following the controversialand briefouster of Sam Altman. According to a New York Times report, Murati had shared her concerns about Altman’s leadership with the board. But after a widespread pushback from employees and investors, Altman was reinstated to the top post, with Murati’s full support. (Murati wrote in a statement in March that her comments to the board about Altman were “all feedback Sam already knew,” adding “I fought their actions aggressively and we all worked together to bring Sam back.”)

In the months since, Murati has played a larger public role at the company. In May, she introduced the company’s new flagship model, GPT-4o, which impressed users with its sophisticated real-time voice interactions. She showcased the company’s progress on SearchGPT, a search engine, and Sora, a text-to-video model. At the Metropolitan Museum of Art’s annual Met Gala, she spoke about OpenAI’s chatbot installation at the museum.

But Murati has also had some high-profile stumbles: When she was asked whether the training data for OpenAI’s video generation model Sora came from copyrighted sources like YouTube, she answered evasively. She provoked another firestorm in June when she claimed that AI would replace some creative jobs that she said perhaps “shouldn’t have been there in the first place.” 

These comments have contributed to a rocky year in the public perception of OpenAI. Meanwhile, Murati and her team are forging ahead with their next generation text model, which Murati predicts will possess the intelligence of a PhD student for some specific tasks—and could arrive in a year.

*Disclosure: OpenAI and TIME have a licensing and technology agreement that allows OpenAI to access TIME's archives.

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Andrew Feldman

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Photo-Illustration by TIME (Source: Courtesy of Andrew Feldman)

Computer chips are like cars, says Andrew Feldman, co-founder and CEO of the AI chip startup, Cerebras Systems. “You make trade offs that are optimized for what the job of the part is: If you want to move bricks and lumber, don't buy a minivan.” But over the past decade, graphical processing units (GPUs), designed for rendering graphics like those in video games, have become the industry standard for machine learning. Feldman and Cerebras are changing that by designing a chip specifically for AI.

“In 2015, we saw the rise of AI on the horizon,” Feldman says. “We asked ourselves, ‘can we make something better for it?’”

Cerebras Systems spent $400 million over three years designing a new semiconductor specifically for AI workloads. The result is what the company calls a Wafer Scale Engine: a dinner plate-sized chip, about 57 times the size of a GPU, making it the largest chip ever. Its third-generation chips can train models in a fraction of the time of GPUs, helping win notable clients including Mayo Clinic and Emirati technology group G42. Cerebras Systems says the new cloud platform it announced in August, built on its chips, can run Meta’s Llama models up to 20 times faster than a cluster of the industry standard Nvidia H100 GPUs, and twice as fast as its competitor Groq’s solution.

Just as improvements in internet speed allowed for the sharing of images, and then the streaming of high-resolution video, advances in the speed of AI chips will open new possibilities, Feldman says. Still, the company is a long way off making a noticeable dent in Nvidia’s more-than-80% share of the AI chip market. “I’m a professional David in the battle of Goliath,” he adds. “Sometimes the best technology doesn't win. We have to try and be sure that it does.”

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Christophe Fouquet

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Photo-Illustration by TIME (Source: Peter Boer—Bloomberg/Getty Images)

Without ASML, the world’s only producer of manufacturing equipment for cutting-edge semiconductors, the AI boom can't happen. That’s how Dutch giant ASML’s former CEO put it to Bloomberg News in January. Normally, one can dismiss such comments from a chief executive as hyperbolic marketing speak. But in ASML’s case, they might be right.

This spring, the company elevated Christophe Fouquet, its former chief business officer to the chief executive position. Fouquet is now responsible for overseeing how ASML responds to the growing demand for semiconductors. It is the only company in the world that builds the machines needed to produce the AI chips designed by heavyweights such as Nvidia.

Its machines, which cost up to $380 million each, are used by semiconductor manufacturers like Taiwan’s TSMC to etch unfathomably small patterns—measured in single-digit nano-meters—in pieces of silicon. Achieving this level of precision involves hitting tiny droplets of molten tin with lasers to emit extreme ultraviolet light, in a technique known as EUV lithography. 

Fouquet also has to navigate the company as it finds itself caught amidst growing U.S.-China tensions. Washington-led export restrictions imposed in January, aimed at curbing China’s access to advanced semiconductors, are expected to reduce the company’s sales in the country by 15%, and the Biden administration is considering tighter controls. Fouquet has previously stated he believes decoupling the global semiconductor supply chain would be “incredibly expensive” if not impossible. He’s also warned that cutting off China may only push the country to develop its own ASML-alternative.

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Brett Adcock

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Photo-Illustration by TIME (Source: Jae C. Hong—AP)

More than 20 million U.S. jobs involve manual labor. Amid growing labor shortages, Brett Adcock’s Figure offers an audacious solution: humanoid robots. The 38-year-old founded the startup in 2022 to create robots that can perform human-like tasks. “The world was built for humans,” Adcock says. “So if we can create a robot that interacts with it in the same way, we can automate a huge range of tasks.”

Others seem to agree. In January 2024, Figure partnered with BMW to integrate their robots into the automaker’s Spartanburg, South Carolina plant. Weeks later, Adcock raised $675 million for the robot startup from investors including OpenAI, Microsoft and Nvidia, as well as Jeff Bezos. Figure is now valued at $2.6 billion.

“We’re in a Goldilocks scenario for AI,” Adcock explains. “This is the first time in human history when this is all possible.” He claims the company’s latest creation, the Figure 02 robot, unveiled in August, can perform 80% to 90% of manual human tasks.
Adcock’s vision extends far beyond factory floors. He predicts a future where everyone owns a humanoid robot, revolutionizing labor markets and the global economy. “Eventually, physical labor will be optional,” he says. “You’ll choose to do it, or you’ll ask your Figure robot to do it.”

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Anant Vijay Singh

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Photo-Illustration by TIME (Source: Courtesy of Anant Vijay Singh)

Beginning last year, a wave of tech giants like Meta, X, Microsoft, and Zoom quietly have updated their terms of service to allow themselves to use customer data to train AI. Since 2014, Proton, the Swiss privacy company, has battled threats to their users’ data from authoritarian regimes and hackers. Now, the threat was coming from within the tech industry itself. For 32-year-old Anant Vijay Singh, Proton’s Product Lead, the mission became urgent. “Challenging Big Tech is hard,” he said. “But that's what excited me.”

Singh is pioneering an approach that harnesses AI to enhance privacy, not compromise it. Under his leadership, Proton introduced three privacy-preserving tools. Sentinel, launched last August, combines AI with human expertise for advanced account protection. In July 2024, Docs, a collaborative editor challenging Google Docs, and Scribe, an AI email writing assistant, followed. Both keep users’ data fully encrypted, enabling workflows free from data-hungry giants like Google, Microsoft, and OpenAI. “We don’t just throw AI on everything,” said Singh. “We saw a use-case that we could solve.”

In a world where the wisdom “if you’re not paying for it, you are the product” rings more true every year, Singh's work at Proton offers a compelling alternative—and it's gaining traction. With more than 100 million users worldwide, Proton's growth suggests a hunger for privacy-focused tech.

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John Jumper

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Photo-Illustration by TIME (Source: Courtesy of John Jumper)

For 60 years, scientists had puzzled over the protein folding problem: There is a vast number of ways a protein can fold, making it difficult to accurately predict. But understanding the relationship between a protein’s 1-dimensional code and its 3-dimensional structure is key to learning more about diseases like Parkinson’s and designing drugs to combat viruses like HIV.

Then, in late 2020, a team from Google DeepMind, led by John Jumper, then a senior research scientist at the organization, cracked it using a machine learning algorithm they called AlphaFold 2. Jumper’s team later released the model on the internet for free.

“What I'm most proud of is the extent to which it's making all of structural biology five or ten per cent faster,” Jumper says. Previously, biologists had to spend years meticulously observing a protein and documenting its structure before starting their experiments, but “Al​​phaFold, in many cases, lets them skip that one or two years,” helping accelerate research on a range of issues from better understanding our cardiovascular system to tackling antibiotic resistance.

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Piotr Dabkowski

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Photo-Illustration by TIME (Source: Courtesy of Piotr Dabkowski)

With just a few minutes of an audio sample, ElevenLabs can clone your voice.

The unicorn start-up, co-founded by two Polish friends, Piotr Dabkowski and Mateusz Staniszewski, has developed a model that can generate a variety of realistic voices from text or pre-existing speech, and be used for dubbing, so that one can appear to sound fluent across 29 languages. 

While only two years old, the company is valued at $1.1 billion and received $80 million from Andreessen Horowitz and others in January. The startup has since partnered with several large brands including HarperCollins, the Washington Post, and TIME. 

ElevenLabs’s model is more robust, has a lower latency, and higher quality than competitors. Dabkowski expects the model to soon hit a “quality ceiling,” where the AI is indistinguishable from any human it mimics.

This poses an obvious safety challenge as it could be used to fraudulent ends, but Dabkowski says that their systems monitor usage to minimize the threat. “We can trace back every single generation, and you need to use your credit card to have access to voice cloning—so it's like using a gun that is connected to the internet,” he says. 

ElevenLabs has developed a speech classifier that can identify whether any audio was generated using their model. The company is also a member of the U.S. AI Safety Institute’s Consortium. Open-source AI audio solutions are a larger concern, Dabkowski adds. Still, some have found ways around some of ElevenLab’s safeguards, and the terrain is constantly evolving, so preventing its misuse may not be so simple.

*Disclosure: TIME and ElevenLabs have a technology agreement to create audio accessible content.

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Lawrence Lek

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Photo-Illustration by TIME (Source: Nishant Shukla—Courtesy of Lawrence Lek)

For the past 10 years, filmmaker Lawrence Lek has been creating science-fiction landscapes that feature neon temples, drones touring abandoned luxury hotels, and empty urban highways.

The throughline is, there are no visible people. His main characters—and crucially, not the villains—are artificial intelligence entities. 

His 2021 film Black Cloud stars a depressed self-driving car that performed its job too well, and finds itself bored and aimless. Meanwhile, his 2017 film Geomancer tells the story of an unfulfilled satellite that returns to earth, longing to become an artist.

These characters deliver poetic, at times morose monologue and dialogue against dreamlike, spacey electronic music.

AI characters, Lek said, can be avatars for outsiders, "or somebody who isn't fully understood yet." He says that treating AI as a threat, in effect, casts it, in human terms, as a fully-fledged adult.  “I actually think it's this adolescent—it's this grumpy teenager who doesn't quite know what they're doing,” Lek says.

As an artist, Lek is an outsider to the AI community, but that perspective allows him to be introspective about the advent of this new technology. Earlier this year, he was awarded the Frieze London 2024 Artist Award. The judges lauded his “essential interrogations into the use of AI and its relationship with the human experience.”

Lek's interest in this storytelling approach was inspired, in part, by growing up in Hong Kong and Singapore, both places that grew and changed rapidly during his childhood.

“It basically didn't seem that science fiction was so much just something that was witnessed in artworks, and in films, and in video games, but it was also something that was part of my everyday life,” Lek says.

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Silvio Savarese

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Photo-Illustration by TIME (Source: Courtesy of Silvio Savarese)

A growing number of companies are using chatbots. Einstein GPT–a generative AI platform which rolled out last year, can go beyond questions and answers and help customers with more complex tasks like product returns or refunds. It is a first-of-its-kind Gen AI geared towards customer relations management (CRM), supercharging the work of sales teams and customer service people around the world.

Silvio Savarese, who leads Einstein GPT, says Salesforce has been betting big on generative AI since before ChatGPT's popularity exploded, developing a large language model to help write code and deploying it for internal and external developers. But now, they are moving into agentic AI, which can work autonomously to help automate things like customer service. It can also flag appropriate sales leads and generate marketing emails and copy.

The company has just released an AI benchmark for customer relationship management, which aims to help businesses make more informed decisions when choosing the best large language models for their business. The benchmark can help businesses choose a leaner, more targeted model rather than a huge one, one that can also come with a smaller carbon footprint than larger more power-hungry models, Savarese says.

*Disclosure: TIME co-chair and owner Marc Benioff is CEO of Salesforce.

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Arthur Mensch

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Photo-Illustration by TIME (Source: Alain Jocard—AFP/Getty Images)

The CEO and co-founder of French unicorn Mistral AI, Arthur Mensch, says he can build cutting-edge models while spending less money and being more open than his Silicon Valley counterparts. His company, named after the Mediterranean wind known for its speed and persistence, has quickly become Europe’s leading AI contender. Since its launch in 2023, Mistral has crossed a reported $6 billion valuation, struck a $16 million deal that gives a minority stake in the company to Microsoft, and partnered with French bank BNP Paribas. The Microsoft deal—which involves Mistral making its models available to Microsoft’s customers in exchange for access to the tech giant’s computational resources—has prompted scrutiny from E.U. lawmakers that it could breach competition rules. But Mensch says Microsoft is just one of four cloud providers the company uses. He has spoken out about other regulation efforts, such as the E.U. AI Act, arguing that such efforts should focus less on general-purpose AI models like Mistral’s and more on regulating how those models are used by others.

Mensch left Google DeepMind in May 2023 to launch Mistral with two former engineering school friends who had been working at Meta. The company has a small but highly specialized team. Mensch told TIME in May that the startup’s focus on releasing large open source models has allowed it to attract roughly 10% of France’s experts in language model development, including top talent from Big Tech competitors.

*Disclosure: Investors in Mistral AI include Salesforce, where TIME co-chair and owner Marc Benioff is CEO.

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Lina Khan

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Photo-Illustration by TIME (Source: Bill O'Leary—The Washington Post/Getty Images)

Federal Trade Commission chair Lina Khan has been a thorn in the side of Big Tech companies since her 2021 appointment, arguing that major players have become too monopolistic and powerful. Over the last year, she’s turned her focus to how these tech giants might be wielding AI to further consolidate their power. In January, the FTC opened an inquiry into the partnerships between Silicon Valley behemoths (Google, Amazon, Microsoft) and rising AI labs (OpenAI, Anthropic), probing whether they might be undermining fair competition. She warned in February that this new technology is in danger of being “co-opted by some of the existing dominant firms to double down on their dominance.”

Khan has sent out many other warning shots to AI companies engaging in questionable practices. She’s declared that any models trained nonconsensually on data from news websites or artists could be in violation of antitrust laws. She has voiced concern about people’s data being used without their knowledge or consent. And she has also proposed new protections against deepfakes. All of these actions, combined with her position of power, make Khan one of the most prominent forces working to combat AI harms today.

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Dan Neely

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Photo-Illustration by TIME (Source: Courtesy of Dan Neely)

Dan Neely was early to spot the potential problems AI-generated deep-fakes would cause celebrities. The serial entrepreneur says he first noticed crypto mining rigs shifting to generate deep fakes around 2018. Not long after, AI-generated videos of rappers like Jay-Z started showing up singing songs like Billy Joel’s “We Didn’t Start the Fire.”

In 2021, Neely founded Vermillio to help celebrities protect their likeness from being misused. The company bills itself as “the first generative AI platform built specifically to protect the work of content creators.” In January, it signed a deal to protect artists represented by the agency WME, which includes artists like Olivia Rodrigo and actors like Hugh Jackman. 

To protect a client, Vermillio ingests all of their content and builds a “holistic likeness model of who that person is,” Neely explains. The company’s software then scans major platforms for possible matches. Neely hopes that in the age of generative AI, Vermillio will eventually become “the blue checkmark of the internet.” 

Customers have the choice of allowing some types of content, like fan art, while prohibiting others, like deepfake pornography. Vermillio also helps artists charge a license for promotional campaigns that may use their likeness. 

At about $4,000 a month, the company is consciously starting “with the world's most beloved IP and talent,” but it will eventually open-source the underlying technology, because Neely believes protecting your likeness is not just something the most privileged should have access to. “It’s a human right,” he says.  

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Willonius Hatcher

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Photo-Illustration by TIME (Source: Courtesy of King Willonius)

This summer, as Kendrick Lamar and Drake fired vicious disses back and forth, an unlikely third party ended up creating one of the defining songs of the high-profile rap feud. King Willonius, a little-known New York-based comedian, used AI tools to create “BBL Drizzy,” a pristine soul song that seemed to be unearthed from the 1970s and whose lyrics lightly mocked Drake. Thousands of people then recorded their own remixes, rap verses, guitar solos, or dances over Willonius’s track, sharing them on platforms like TikTok.

For King Willonius—whose real name is Will Hatcher—the success of “BBL Drizzy” served as the gratifying payoff for months of experimentation with AI tools. In 2023, Hatcher was trying to make it as a comedy writer in Los Angeles when the writers strike began, snuffing out the pitch meetings he had lined up with agents and managers. To fill his time and to challenge himself, Hatcher began playing with AI tools for more than eight hours a day: creating movie trailers with Runway, fanciful images with MidJourney, pitch decks with ChatGPT and new songs with Udio and Suno. “Everything unlocked for me: It felt like I now had the resources to create anything I could imagine,” Hatcher tells TIME. 

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Palmer Luckey

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Photo-Illustration by TIME (Source: Kyle Grillot—Bloomberg/Getty Images)

With his defense technology startup Anduril Industries, Palmer Luckey is betting that the future of military technology lies in advances in software engineering and computing. And with a valuation of $14 billion, investors in the company seem to agree.

Anduril—named after a sword from Lord of the Rings meaning “flame of the west”—has gained a reputation as a disruptor in the defense sector. The company counts the U.S. Department of Defense, the U.K. Ministry of Defence, and the Australian Defence Force among its clients. It has sold more than a dozen autonomous defense and weapons systems to the U.S. since it was founded in 2017.

These systems—which include autonomous drones, rockets, and submarines—are primarily powered by Anduril’s Lattice OS, which it describes as an “AI-powered open operating system” that integrates AI-driven decision-making with flexible, scalable hardware.

Describing Anduril’s ALTIUS drone in an interview with NPR, Luckey explained that the drone has “a Lattice brain” that is able to seek and identify targets and fly into them, “even if they’re jamming you."

Anduril’s tech is quickly spreading across the world. One of its first contracts was to supply AI-driven surveillance towers along the U.S.-Mexico border for the Trump administration. The company’s drones were in Ukraine by the second week of the war, its software continuously updated remotely. Anduril’s newest venture, “Arsenal” aims to use a software platform—and associated manufacturing facilities—to “hyperscale” hardware manufacturing.

Luckey previously spun up one of the first virtual reality startups, Oculus VR, for which he graced a 2015 cover of TIME, before selling it to Facebook for $2 billion in 2014 at the age of 21. He has been described as having a worldview of hyper-techno-optimism and is a Republican donor, but he has said he believes his business is set to benefit regardless of political administration.

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Tekedra Mawakana

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Photo-Illustration by TIME (Source: Travis P. Ball—SXSW/Getty Images)

The mission of driverless taxi company Waymo is downright audacious, says co-CEO Tekedra Mawakana: “to be the world's most trusted driver, and at the same time, do something that's never been done before.” The company was the first to expand AI-driven taxis into major metropolitan areas, starting with San Francisco and Phoenix, and this year expanding into the largest yet—Los Angeles. It’s focused on Austin after that.

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Chris Mansi

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Photo-Illustration by TIME (Source: Courtesy of Chris Mansi)

When someone is having a stroke, they lose 2 million brain cells every minute. It’s a leading cause of disability and death globally. Chris Mansi, a neurosurgeon turned co-founder of Viz.AI, wants to help people get the care they need much faster.

The company’s algorithms, which analyze a patient’s various tests and scans to help diagnose stroke and other emergencies, can already shave off 66 minutes of the time it takes for stroke patients to receive specialized care. “That is equivalent to reducing disability by one year,” Mansi says. The algorithm’s success has led to Viz.ai deploying it in over 1,600 hospitals.

The company’s platform also facilitates communication with specialists at different hospitals, helping ensure those in rural areas or underserved communities with very few medical providers, can get to the right specialists in time. Mansi explains: “We’re not just detecting the stroke, but we're sending an alert to the neurosurgeon in that specialist hospital,” empowering doctors to decide much faster whether transferring the patient is required.  

Mansi co-founded Viz.ai in 2016 while in the Stanford MBA program. Eric Schmidt, former Google CEO, who was also his professor, decided to seed-fund the company. In 2018, Viz.ai’s stroke algorithm became the first of its kind to receive FDA approval. Since then, the company has continued to grow the types of data and list of conditions it can detect, boasting a total of 13 FDA-approved algorithms that can help triage a range of heart, lung and brain conditions.

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Ray Kurzweil

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T100 AI Ray Kurzweil
Photograph by Alana Paterson

Ray Kurzweil's eerily prescient predictions about AI are underpinned by a simple line chart. The chart, tracking the amount of computing power you could buy for a dollar over time, has grown exponentially for the past 85 years. Kurzweil initially used it to prioritize his inventions as a young programmer, focusing on a revolutionary print-to-speech machine for the blind in the 1970s, then early speech recognition software in the '80s. Eventually, he started writing about what he believed advances in computing power would bring and his predicting “took on a life of its own."

In 1990, Kurzweil correctly projected that AI would beat the best human player at chess before the turn of the millennium, and that mobile devices connected to a global information network would emerge in the decade that followed. In 1999, he forecast that by 2029, computers would match human intelligence in every domain. At the time, leading researchers like Geoffrey Hinton and Yoshua Bengio thought it would take much longer. They have since changed their tune.

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Ilya Sutskever

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Photo-Illustration by TIME (Source: Jack Guez—AFP/Getty Images)

OpenAI’s former chief scientist has had a tumultuous year. Ilya Sutskever, once widely regarded as perhaps the most brilliant mind at OpenAI, voted in his capacity as a board member last November to remove Sam Altman as CEO. The move was unsuccessful, in part because Sutskever reportedly bowed to pressure from his colleagues and reversed his vote. After those fateful events, Sutskever disappeared from OpenAI’s offices so noticeably that memes began circulating online asking what had happened to him. Finally, in May, Sutskever announced he had stepped down from the company.

On X (formerly Twitter), Sutskever praised OpenAI’s leadership and said he believed the company would build AGI safely. But his departure came at the same time as several other safety-focused staff left with more pessimistic public statements about OpenAI’s safety culture, which seemed to underline the impression that something fundamental had shifted at the company. The Superalignment team that Sutskever co-ran, which was aimed at developing methods to make advanced AIs controllable so they don’t wipe out humanity, had been promised 20% of OpenAI’s computing power to do its work. But the team sometimes struggled to access that compute and was increasingly “sailing against the wind,” Sutskever’s co-lead Jan Leike said in a series of messages announcing his own departure, in which he criticized the safety culture at OpenAI as having “taken a backseat” to building new “shiny products.” 

In June, Sutskever announced he was starting a new AI company, called Safe Superintelligence, which aims to build advanced AI outside of the market, to avoid becoming “stuck in a competitive rat race.” The implication that OpenAI is stuck in such a rat race is the most critical Sutskever has been of his former employer in public. 

Safe Superintelligence is at least the third AI company—after OpenAI and Anthropic—to be founded by industry insiders on the belief that they could build superintelligent AI more safely than their irresponsible competitors. But so far at least, with each new entrant, the race has only accelerated. Sutskever declined a request to be interviewed for this story via a spokesperson, who said he was in “what he describes as Monk Mode—heads down in the lab.”

*Disclosure: OpenAI and TIME have a licensing and technology agreement that allows OpenAI to access TIME's archives.

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Albert Gu

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Photo-Illustration by TIME (Source: Courtesy of Albert Gu)

Albert Gu, assistant professor of machine learning at Carnegie Mellon University, is working on giving artificial intelligence something akin to memory.

Currently, every time you ask models like ChatGPT a question, it considers every prior bit of information the user has provided before generating a response. This is the way most large language models (LLMs) work and contributes to the lag users experience when chatting with the AI. 

Gu, who is also a co-founder of the AI startup Cartesia, has developed a new way of designing models that allows the AI to compress every prior data point into a “summary of everything” it has seen before, Gu describes. In a paper published in December, Gu introduced this design, called “Mamba,” which gives models something like a working memory. This potentially makes them faster than traditional LLMs, and much more efficient in how they draw on computing power, particularly in domains beyond language, such as audio and genetics. The approach seems to be taking off: Abu Dhabi's Technology Innovation Institute (TII) has implemented Gu's Mamba architecture in their Falcon Mamba 7B model, creating one of the world's first open-source models to use this technology. 

Gu, who has been working on this approach for almost five years alongside his colleague Princeton University professor Tri Dao, and others, emphasizes that the design approach represented by Mamba offers a “different paradigm of working with data.” Like many in the field, his ultimate goal is a system general enough to handle anything.

Gu believes his work at Carnegie and Cartesia shows there are many paths development of artificial intelligence could follow.  “Even just the proof of concept that there are companies who have scaled these models—really good models—based on these alternate architectures offers an important signal to open source and academic communities,” Gu says

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Andrej Karpathy

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Photo-Illustration by TIME (Source: Courtesy of Andrej Karpathy)

Andrej Karpathy’s name is strewn across the history of modern AI. In 2015, he was one of the founding members of OpenAI, working as a research scientist. In 2017, he was personally hired by Elon Musk to lead Tesla’s work on computer vision. He later returned to OpenAI in 2023 to work on improving GPT-4. His biggest impact on the world, however, may come not from his research but from his role as one of the world’s foremost educators on neural networks.

In 2015, Karpathy, alongside his colleague Professor Fei-Fei Li, designed Stanford University’s first course dedicated to deep-learning, for which he was the primary instructor. Videos of his lectures have been viewed over 800,000 times. Since then, he has become one of the internet’s most-beloved AI instructors. In recent years, Karpathy has explained intricate subjects like how to build smaller versions of GPT from scratch to a YouTube audience of millions.

“I’m a little bit obsessed with coming to the core of things, ” Karpathy says. He credits this to his physics education, which makes him adept at finding the simplest explanations to complex issues. 

Karpathy draws inspiration from figures like Richard Feynman, renowned for his contributions to both research and public education. “People are obviously pre-money if they’re trying to learn a lot of stuff”, he says. “So I get paid in people thanking me.”

His latest venture, Eureka Labs, founded July 2024, aims to build a school that is “AI native.” Its first product will be an undergraduate-level course on AI, designed by a human and guided by an AI teaching assistant. When he first built his AI course at Stanford nine years ago, he was working part-time, and it was done over a few months. “It was a successful course,” he says, “But I think if I really focus on this, I can do a lot better.”

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Andrew Yao

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Photo-Illustration by TIME (Source: Courtesy of Andrew Yao)

Andrew Yao, widely-considered to be one of the most influential computer scientists of his generation, has left an indelible imprint on China’s approach to AI.

A Turing Award winner and the Dean of the Institute for Interdisciplinary Information Sciences at Tsinghua University, Yao has reportedly shaped some of China's biggest AI startups and a generation of academics. His students have gone on to found companies worth billions of dollars, like the software company Megvii and the autonomous vehicle company Pony.ai. Others have secured positions at top universities like Stanford and Princeton.

Since 2018, Yao has established four different AI Institutes across China, focusing on foundational research. Already in 2024, he has been appointed as head of Tsinghua’s newly-created College of AI, and was praised by President Xi Jinping for his unwavering dedication and remarkable achievements in teaching and research.
Yao has also become a leading voice in discussions of AI safety, vocal on the potentially catastrophic risks posed by future systems that might autonomously execute cyberattacks or assist in creating weapons of mass destruction.

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Iason Gabriel

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Photo-Illustration by TIME (Source: Courtesy of Iason Gabriel)

Iason Gabriel is a rare sight at a big tech company: a political theorist with a Ph.D. from the University of Oxford. He’s Google DeepMind’s point-man on the philosophical underpinnings of AI “alignment,” or the question of how to define the ethical values to which AI should be held. And in April, he co-authored a 274-page paper on the ethics of AI agents—bots that can take actions in the real world, which many AI companies believe are just around the corner. The paper was perhaps the most comprehensive look yet from inside a leading AI company at the constraints that should be placed on more autonomous forms of AI, and how companies should balance the sometimes competing demands of themselves, their users, and society at large. It is among the first steps, Gabriel says, in Google’s effort to anticipate how AI agents might change the world, and it will influence how the company designs both its new AI systems and the rules that govern them.

Among the paper’s recommendations: AI companies should avoid making their AI agents too human-like, and that agents should always disclose that they are AIs rather than humans. Tech companies must do all they can to not exploit the trust placed in them by users who might disclose to agents their sensitive personal data, the paper says. And AI companies must carefully consider what actions their agents should, firstly, be able to take automatically; secondly, require human confirmation for; and, thirdly, be prohibited from doing entirely.

The work of Gabriel and his colleagues has the potential to set the tone for how Google, which has billions of users worldwide, rolls out a potentially transformative new technology. But Google has gone against its own warnings before. In 1998, a paper published by Google’s co-founders Larry Page and Sergey Brin warned that any future advertising-funded search engines would “be inherently biased towards the advertisers and away from the needs of consumers.” The company now makes most of its money from advertising.

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Helen Toner

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Photo-Illustration by TIME (Source: Courtesy of Helen Toner)

In mid-November of 2023, Helen Toner made what will likely be the most pivotal decision of her career.

Together with three other members of OpenAI’s board, she voted to fire Sam Altman from his role as the company’s CEO. At the time, Toner and her fellow board members were silent about their reasons, saying only that Altman had “not been consistently candid” with them. In the information vacuum, a pressure campaign by Altman’s allies to reinstate him gained momentum. Silicon Valley luminaries, venture capitalists, and OpenAI’s biggest investor, Microsoft, joined the effort—as did most of OpenAI’s employees, whose equity in the company appeared to be at risk of losing most or all of its value. Five days later, Altman was back in the CEO’s chair. Outmaneuvered, Toner and all but one of the other board members who fired Altman agreed to step down. 

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Amanda Askell

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Photo-Illustration by TIME (Source: Courtesy of Amanda Askell)

Amanda Askell’s nickname at Anthropic, the AI firm where she works, is the “Claude whisperer.”

Anthropic’s chatbot, Claude, has a reputation in the industry for being friendly, curious, and maybe a little more creative than its main rival ChatGPT. Askell is more responsible than anyone else for this thoughtfully engineered persona.

A philosopher by training, she leads the team at Anthropic that’s responsible for embedding Claude with certain personality traits and avoiding others. “It feels important to have a nuanced, rich conception of what it is to be good,” Askell says in an interview at Anthropic’s San Francisco headquarters. 

In an effort to help Claude be “good,” Askell has tuned it to openly admit to users when it’s unsure of its answer, to attempt to discuss ideas without bias, and to avoid both-sidesism when discussing settled issues like climate change. Most importantly, she’s engineered Claude to tell people it doesn't have feelings, memory, or self-awareness—that any personality that it might display is the product of complex language processing rather than evidence of an inner life.

In spite of all these measures, or perhaps because of them, there’s still something seemingly human-like about Claude’s personality. 

Some argue that making chatbots behave too anthropomorphically carries risks, including encouraging people to have inappropriate relationships with AI, or fostering inaccurate perceptions of how the technology actually works. But Askell is betting that in some scenarios, emulating human behavior can help users avoid falling into the dangerous trap of believing AI is all-knowing. “I was a bit worried about this idea that if you have this thing that feels robotic, that people might think of it as this authority,” she says, referring to the long-observed pattern of humans placing undue trust in machines. “The more you can signal that you’re talking with something that isn’t this grand source of authority on everything,” she says, it’s also more likely that people won't believe Claude’s outputs at face value. “It may feel more human-like—but that’s the line that you have to tread.”

*Disclosure: Investors in Anthropic include Salesforce, where TIME co-chair and owner Marc Benioff is CEO.

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