Nitric oxide induces hypoxia-inducible factor 1 activation that is dependent on MAPK and phosphatidylinositol 3-kinase signaling

Kenji Kasuno, Satoshi Takabuchi, Kazuhiko Fukuda, Shinae Kizaka-Kondoh, Junji Yodoi, Takehiko Adachi, Gregg L. Semenza, Kiichi Hirota

Induction of Hypoxia-inducible Factor 1 Activity by Muscarinic Acetylcholine Receptor Signaling

Kiichi Hirota, Ryo Fukuda, Satoshi Takabuchi, Shinae Kizaka-Kondoh, Takehiko Adachi, Kazuhiko Fukuda, Gregg L. Semenza

Selective Killing of Hypoxia-Inducible Factor-1–Active Cells Improves Survival in a Mouse Model of Invasive and Metastatic Pancreatic Cancer

Shinae Kizaka-Kondoh, Satoshi Itasaka, Lihua Zeng, Shotaro Tanaka, Tao Zhao, Yumi Takahashi, Keiko Shibuya, Kiichi Hirota, Gregg L. Semenza, Masahiro Hiraoka

VHL-deficient renal cancer cells gain resistance to mitochondria-activating apoptosis inducers by activating AKT through the IGF1R-PI3K pathway

Ryuji Yamaguchi, Hiroshi Harada, Kiichi Hirota

Polysulfide inhibits hypoxia-elicited hypoxia-inducible factor activation in a mitochondria-dependent manner

Takeo Uba, Yoshiyuki Matsuo, Chisato Sumi, Tomohiro Shoji, Kenichiro Nishi, Munenori Kusunoki, Hiroshi Harada, Hideo Kimura, Hidemasa Bono, Kiichi Hirota

FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

Patrick C. Mahon, Kiichi Hirota, Gregg L. Semenza

Activation of hypoxia-inducible factor 1 during macrophage differentiation

Tomoyuki Oda, Kiichi Hirota, Kenichiro Nishi, Satoshi Takabuchi, Seiko Oda, Hiroko Yamada, Toshiyuki Arai, Kazuhiko Fukuda, Toru Kita, Takehiko Adachi, Gregg L. Semenza, Ryuji Nohara

Persisting mild hypothermia suppresses hypoxia-inducible factor-1alpha protein synthesis and hypoxia-inducible factor-1-mediated gene expression

Tomoharu Tanaka, Takuhiko Wakamatsu, Hiroki Daijo, Seiko Oda, Shinichi Kai, Takehiko Adachi, Shinae Kizaka-Kondoh, Kazuhiko Fukuda, Kiichi Hirota

Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia

Sonny O. Ang, Hua Chen, Kiichi Hirota, Victor R. Gordeuk, Jaroslav Jelinek, Yongli Guan, Enli Liu, Adelina I. Sergueeva, Galina Y. Miasnikova, David Mole, Patrick H. Maxwell, David W. Stockton, Gregg L. Semenza, Josef T. Prchal

The antioxidant N-acetyl cysteine suppresses lidocaine-induced intracellular reactive oxygen species production and cell death in neuronal SH-SY5Y cells

Akihisa Okamoto, Masahiro Tanaka, Chisato Sumi, Kanako Oku, Munenori Kusunoki, Kenichiro Nishi, Yoshiyuki Matsuo, Keizo Takenaga, Koh Shingu, Kiichi Hirota

Fentanyl activates hypoxia-inducible factor 1 in neuronal SH-SY5Y cells and mice under non-hypoxic conditions in a μ-opioid receptor-dependent manner

Hiroki Daijo, Shinichi Kai, Tomoharu Tanaka, Takuhiko Wakamatsu, Shun Kishimoto, Kengo Suzuki, Hiroshi Harada, Satoshi Takabuchi, Takehiko Adachi, Kazuhiko Fukuda, Kiichi Hirota

Rac1 activity is required for the activation of hypoxia-inducible factor 1

Kiichi Hirota, Gregg L. Semenza

Hydrogen sulfide inhibits hypoxia- but not anoxia-induced hypoxia-inducible factor 1 activation in a von hippel-lindau- and mitochondria-dependent manner

Shinichi Kai, Tomoharu Tanaka, Hiroki Daijo, Hiroshi Harada, Shun Kishimoto, Kengo Suzuki, Satoshi Takabuchi, Keizo Takenaga, Kazuhiko Fukuda, Kiichi Hirota

Differential roles of prostaglandin E-type receptors in activation of hypoxia-inducible factor 1 by prostaglandin E1 in vascular-derived cells under non-hypoxic conditions

Kengo Suzuki, Kenichiro Nishi, Satoshi Takabuchi, Shinichi Kai, Tomonori Matsuyama, Shin Kurosawa, Takehiko Adachi, Takayuki Maruyama, Kazuhiko Fukuda, Kiichi Hirota

Cigarette smoke reversibly activates hypoxia-inducible factor 1 in a reactive oxygen species-dependent manner

Hiroki Daijo, Yuma Hoshino, Shinichi Kai, Kengo Suzuki, Kenichiro Nishi, Yoshiyuki Matsuo, Hiroshi Harada, Kiichi Hirota