●韓国人の遺伝子の特徴について 米人類学者Cavalii-Sforzaの遺伝子勾配データによれば、 朝鮮人は世界でも類を見ないほど均一なDNA塩基配列の持ち主であり、 これは過去において大きな Genetic Drift(少数の人間が近親相姦を重ねて今の人口動態を形成)か 、あるいは近親相姦を日常的に繰り返す文化の持ち主だった事を表します。 (文献:The Great Human Diasporas: The History of Diversity and Evolution. 1995.. Luigi Luca Cavalii-Sforza and Francesco Cavalli-Sforza. Addison Wesley Publ. ISBN 0-201-44231-0)
アメリカ食品医薬品局(FDA)が2014年に発表した論文は、下記のように韓国人の遺伝子・DNAの質的な特異性を明確に指摘しています。
(原文から引用)
「 In contrast with the SNVs common to other populations in HapMap and 1KGP, the Korean only SNVs had high percentages of non-silent variants, emphasizing the unique roles of these Korean only SNVs in the Korean population.」
①「Therefore, we rationally conjectured that Korean only SNVs prevalent across many of the individuals would be more important for treating Koreans differently from other populations in the personalized medicine.」
②「We analyzed disease association by WebGestalt using the genes involved in non-synonymous SNVs in SNV-1 and SNV-35.
Therefore, we inferred that special attention should be made for the Korean population when treated for the above mentioned terms related diseases, since other populations did not carry those Korean only SNVs. 」
(論文末尾に、略語一覧がありますので、参考までに)
SNV:single nucleotide variant
SNV-1:SNVs detected in at least one of the 35 Korean individuals but not included in either HapMap or 1KGP
SNV-35:SNVs detected in all of 35 Korean individuals but not included in either HapMap or 1KGP